Sodium Hydroxide → 1-Isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxylic acid

HRID 1290897

反応式

HRID 1290897 の反応式
[CH:1]([N:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=[C:6]([C:14]([O:16]CC)=[O:15])[C:5]1=[O:19])([CH3:3])[CH3:2].[OH-].[Na+]>C(O)C.O>[CH:1]([N:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=[C:6]([C:14]([OH:16])=[O:15])[C:5]1=[O:19])([CH3:3])[CH3:2]

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 15468682Ethyl 1-isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxylate

生成物 1

HCID 109442901-Isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxylic acid収率 17.4%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

A solution of 1.55 g of ethyl 1-isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxylate and 0.28 g of sodium hydroxide in 10 ml of ethanol and 2 ml of water was stirred overnight at room temperature. The solvent was distilled off and dil. hydrochloric acid was added to the residue. The precipitated solid was filtered, washed with water and dried to give 0.24 g of 1-isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxylic acid.

後処理

  1. distillationThe solvent was distilled off
  2. additiondil. hydrochloric acid was added to the residue
  3. filtrationThe precipitated solid was filtered
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-fa87404ba9ff4efb811ae747441d3c4e
出典データセット
uspto-grants-1998_05
特許番号
US05753673

関連ノート

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