Sodium Hydroxide → 1-Isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxylic acid
反応式
[CH:1]([N:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=[C:6]([C:14]([O:16]CC)=[O:15])[C:5]1=[O:19])([CH3:3])[CH3:2].[OH-].[Na+]>C(O)C.O>[CH:1]([N:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=[C:6]([C:14]([OH:16])=[O:15])[C:5]1=[O:19])([CH3:3])[CH3:2]参加物
5
実験手順
A solution of 1.55 g of ethyl 1-isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxylate and 0.28 g of sodium hydroxide in 10 ml of ethanol and 2 ml of water was stirred overnight at room temperature. The solvent was distilled off and dil. hydrochloric acid was added to the residue. The precipitated solid was filtered, washed with water and dried to give 0.24 g of 1-isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxylic acid.
後処理
- distillationThe solvent was distilled off
- additiondil. hydrochloric acid was added to the residue
- filtrationThe precipitated solid was filtered
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-fa87404ba9ff4efb811ae747441d3c4e
- 出典データセット
- uspto-grants-1998_05
- 特許番号
- US05753673
反応ノート
読み込み中…