Sodium Hydroxide → HCID 18387469、化合物

HRID 1290918ノート

反応式

HRID 1290918 の反応式
[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:31])=[C:6]([CH:30]=1)[C:7]([N:9](C(=O)C1C=C(F)C=CC=1C)[C:10]1[N:15]=[CH:14][C:13]([C:16]([O:18]C)=[O:17])=[CH:12][CH:11]=1)=[O:8].[OH-].[Na+]>CO.O1CCCC1>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:31])=[C:6]([CH:30]=1)[C:7]([NH:9][C:10]1[N:15]=[CH:14][C:13]([C:16]([OH:18])=[O:17])=[CH:12][CH:11]=1)=[O:8]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 22099733Methyl 6-[[bis(5-fluoro-2-methylbenzoyl)]amino]pyridine-3-carboxylate

生成物 1

HCID 18387469HCID 18387469、化合物収率 81.2%

試薬・触媒・溶媒 1

HCID 21899815MeOH tetrahydrofuran溶媒

実験手順

A mixture of 12.0 g of methyl 6-[[bis(5-fluoro-2-methylbenzoyl)]amino]pyridine-3-carboxylate, 60 ml of methanol-tetrahydrofuran (1:1) and 23 ml of 5N NaOH is stirred at room temperature for 16 hours. The mixture is concentrated under vacuum, diluted with 25 ml of water, cooled and acidified with 1N HCl. The mixture is filtered and the solid washed with water to give 6.3 g of the product as a white solid.

後処理

  1. concentrationThe mixture is concentrated under vacuum
  2. additiondiluted with 25 ml of water
  3. temperaturecooled
  4. filtrationThe mixture is filtered
  5. washthe solid washed with water

出典と根拠

ORDレコード
ord-980b53758d9b410fb2bbbf978fdd0ade
出典データセット
uspto-grants-1998_05
特許番号
US05753648

反応ノート

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