Water → 2-(Pyridin-2-YL)benzoic acid

HRID 1290942

反応式

HRID 1290942 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:16]=[CH:15][CH:14]=[CH:13][C:8]=1[C:9]([O:11]C)=[O:10].[OH-].[Na+].O>CO>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:16]=[CH:15][CH:14]=[CH:13][C:8]=1[C:9]([OH:11])=[O:10]

参加物

5

反応物 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 13417093Methyl 2-(2-pyridinyl)benzoate

生成物 1

HCID 157331752-(Pyridin-2-YL)benzoic acid収率 89.2%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 3.0 g of methyl 2-(2-pyridinyl)benzoate and 600 mg of sodium hydroxide in 50 ml of 9:1 methanol:water is refluxed for 4 hours. The reaction mixture is concentrated in vacuo and the residue dissolved in 50 ml of cold water. The solution is neutralized with glacial acetic acid and the resulting product filtered, washed with water, and dried to give 2.5 g of the desired product:M+1=200.

後処理

  1. concentrationThe reaction mixture is concentrated in vacuo
  2. dissolutionthe residue dissolved in 50 ml of cold water
  3. filtrationthe resulting product filtered
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-913a93ba2ddf493880cb0f4d3bcc811c
出典データセット
uspto-grants-1998_05
特許番号
US05753648

関連ノート

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