Acetic Acid → 2-Chloro-5-ethylpyridine

HRID 129101ノート

反応式

HRID 129101 の反応式
[N:1]1([CH:6]=[CH:7][C:8]#N)[CH2:5][CH2:4][CH2:3][CH2:2]1.N1(C=CCC)CCCC1.C(O)(=O)C.[ClH:23]>C(Cl)(Cl)Cl>[Cl:23][C:6]1[CH:7]=[CH:8][C:4]([CH2:3][CH3:2])=[CH:5][N:1]=1

参加物

6

反応物 4

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 1396491-But-1-enylpyrrolidineHCID 12732581beta-Pyrrolidino-acrylonitrile

生成物 1

HCID 111263632-Chloro-5-ethylpyridine

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

19.3 g of β-pyrrolidino-acrylonitrile were added at -10° C. to 30 g of pyrrolidino-butene from A4 in 50 ml of chloroform. The mixture was allowed to warmto RT, and 50 ml of acetic acid were added dropwise. After stirring at RT for 15 hours, the mixture was cooled to -10° C., and dry hydrogen chloride gas was introduced. Aqueous workup gave 2-chloro-5-ethylpyridine as the main product.

後処理

  1. customto warmto RT
  2. temperaturethe mixture was cooled to -10° C.

出典と根拠

ORDレコード
ord-14b569afbedf4364a9df29d744aacb65
出典データセット
uspto-grants-1995_11
特許番号
US05466800

反応ノート

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