2-Amino-2-methyl-1-propanol → Tert-butyl 2-(1-hydroxy-2-methylpropan-2-yl)hydrazine-1-carboxylate

HRID 12913

反応式

HRID 12913 の反応式
[C:1]([O:5][C:6]([N:8]1C(C2C=CC(C#N)=CC=2)O1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH2:19][C:20]([CH3:24])([CH3:23])[CH2:21][OH:22]>C(OCC)C>[C:1]([O:5][C:6]([NH:8][NH:19][C:20]([CH3:24])([CH3:23])[CH2:21][OH:22])=[O:7])([CH3:2])([CH3:3])[CH3:4]

参加物

4

反応物 2

HCID 118072-Amino-2-methyl-1-propanolHCID 2725038N-Boc-3-(4-cyanophenyl)oxaziridine

生成物 1

HCID 54541694Tert-butyl 2-(1-hydroxy-2-methylpropan-2-yl)hydrazine-1-carboxylate収率 40%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

A solution of N-(tert-butoxycarbonyl)-3-(4-cyanophenyl)-oxaziridine (CAS #: 150884-56-3, purchased from Acros, 5.17 g, 21 mmol) in anhydrous diethyl ether (20 mL) was added to a solution of 2-amino-2-methyl-propan-1-ol (1.78 g, 20 mmol) in anhydrous diethyl ether (20 mL) at room temperature. The reaction mixture stirred at room temperature for 2 hours. Diethyl ether was evaporated under reduced pressure and the residue was purified by flash chromatography eluting with a gradient of 3-5% methanol/dichloromethane to give N′-(2-hydroxy-1,1-dimethyl-ethyl)-hydrazinecarboxylic acid tert-butyl ester (1.63 g, 40%) which was used without further purification.

後処理

  1. customDiethyl ether was evaporated under reduced pressure
  2. customthe residue was purified by flash chromatography
  3. washeluting with a gradient of 3-5% methanol/dichloromethane

出典と根拠

ORDレコード
ord-279d0f43f58a4171a279e21137b58bb2
出典データセット
uspto-grants-2010_06
特許番号
US07728029B2

関連ノート

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