2-アミノ-2-メチル-1-プロパノール

Nitrogen Compounds -> Amines, Aliphatic

Flammable agents - 2nd degree

Cosmetic ingredients (Aminomethyl Propanol) -> CIR (Cosmetic Ingredient Review)

Cosmetic ingredients (Aminomethylpropanol) -> CIR (Cosmetic Ingredient Review)

Buffering

0.935 (USCG, 1999) - Less dense than water; will float

0.934 @ 20 °C/20 °C

0.93 g/cm³

0.935

0.934 @25 °C

MISCIBLE WITH WATER; SOL IN ALCOHOLS

Solubility in water: miscible

153 °F (USCG, 1999)

67 °C

67 °C CC

67 °C c.c.

153 °F

329 °F at 760 mmHg (99+% compound) (USCG, 1999)

165 °C @ 760 MM HG

165 °C

329 °F

165 °C @760 [mm Hg]

89.6 °F (USCG, 1999)

31 °C

31 °C

89.6 °F

3.0 (AIR= 1)

Relative vapor density (air = 1): 3.0

1.0 [mmHg]

Vapor pressure, Pa at 20 °C: 133

Warning

H315: Causes skin irritation [Warning Skin corrosion/irritation]

P264, P264+P265, P273, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, P362+P364, and P501 (click each P-code to see the statement)

This chemical does not meet GHS hazard criteria for 0.3% (12 of 4294) of reports.

Warning

H315 (99.7%): Causes skin irritation [Warning Skin corrosion/irritation]

Chemical: 1-Propanol, 2-amino-2-methyl-

1-Propanol, 2-amino-2-methyl- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1-Propanol, 2-amino-2-methyl- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

REACH registered substance: 2-amino-2-methylpropanol (EC: 204-709-8)

2-Amino-2-methyl-1-propanol: Does not have an individual approval but may be used under an appropriate group standard

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

Special Hazards of Combustion Products: Emits toxic fumes during fire conditions. (USCG, 1999)

Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Above 67 °C explosive vapour/air mixtures may be formed.

Causes severe irritation. Inhalation may be fatal as a result of spasm, inflammation, and edema of laryns and bronchi, chemical pneumonitis, and pulmonary edema. Symptoms of exposure may include burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea and vomiting. (USCG, 1999)

Corrosive to the eyes; A respiratory tract and severe skin irritant; May cause liver injury if ingested; [ICSC] May cause skin irritation after prolonged contact; Emergency treatment: Irritants; [HSDB] Highly irritating or corrosive to rabbit skin; Not sensitizing to guinea pig skin in the Buehler Test; Histopathological changes to liver observed in 28-day and 3-month feeding studies of dogs; [IUCLID] Irritating to skin; May be corrosive to eye; Harmful to aquatic organisms; [Alfa Aesar MSDS] Skin designation; [MAK]

2-AMINO-2-METHYL-1-PROPANOL is an organic compound with both amine and alcohol substituents. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

2 - Materials that, under emergency conditions, can cause temporary incapacitation or residual injury.

2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials would not under normal conditions form hazardous atmospheres with air, but under high ambient temperatures or under moderate heating could release vapor in sufficient quantities to produce hazardous atmospheres with air.

0 - Materials that in themselves are normally stable, even under fire conditions.

2 - Materials that, under emergency conditions, can cause temporary incapacitation or residual injury.

2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials would not under normal conditions form hazardous atmospheres with air, but under high ambient temperatures or under moderate heating could release vapor in sufficient quantities to produce hazardous atmospheres with air.

0 - Materials that in themselves are normally stable, even under fire conditions.

Excerpt from ERG Guide 128 [Flammable Liquids (Water-Immiscible)]:

Use water spray, powder, alcohol-resistant foam, carbon dioxide.

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer for medical attention .

Personal protection: filter respirator for organic gases and particulates adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org

Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org

Cough. Sore throat.

Redness. Pain.

Redness. Pain. Severe deep burns.

Abdominal pain. Burning sensation.

PROLONGED SKIN EXPOSURE MAY CAUSE IRRITATION DUE TO THE ALKALINITY OF THE FREE MATERIAL...

...IN MOST COMMERCIAL FORMULAS /OF 2-AMINO-2-METHYL-1-PROPANOL/...ALKALINITY IS NEUTRALIZED.

METABOLISM AND DISTRIBUTION OF (3)H-LABELED 2-AMINO-2-METHYLPROPANOL WAS STUDIED IN RATS RECEIVING NORMAL OR CHOLINE-DEFICIENT DIETS. TRITIUM APPEARED IN THE SERUM OF BOTH GROUPS 30 MIN AFTER THE IP INJECTION BUT THE LEVEL WAS GENERALLY LOWER IN THE CHOLINE-DEFICIENT GROUP. RATS ON THE NORMAL DIET EXCRETED MORE OF THE AMINO ACID IN THE URINE THAN DID THE CHOLINE-DEFICIENT RATS IN BOTH GROUPS ONLY THE UNCHANGED AMINO ACID WAS EXCRETED. LIVERS FROM THE CHOLINE-DEFICIENT GROUP HAD A GREATER UPTAKE AND RETENTION OF THE LABEL THAN THOSE FROM NORMAL RATS. MOST OF THE LABEL WAS FOUND IN THE CYTOSOL OF BOTH LIVER AND KIDNEY.

CIR ingredient: Aminomethyl Propanol

CIR ingredient: Aminomethylpropanol

Used to make other chemicals (surface-active agents, vulcanization accelerators, and pharmaceuticals) and as an emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, leather dressings, textile specialties, polishes, cleaning compounds, and so-called soluble oils; Also used in hair sprays, wave sets, hair dyes, Pamabrom (drug), and absorbents for acidic gases; [Merck Index] Used as a pigment dispersant for water-based paints, resin solubilizer, corrosion inhibitor, protecting agent for carbonyl groups and in boiler-water treatment; [CHEMINFO]

Painting (Pigments, Binders, and Biocides) [Category: Paint]

IN SYNTH OF SURFACE-ACTIVE AGENTS, VULCANIZATION ACCELERATORS, PHARMACEUTICALS; ABSORBENT FOR ACIDIC GASES; EMULSIFYING AGENT FOR COSMETIC CREAMS AND LOTIONS, MINERAL OIL & PARAFFIN WAX EMULSIONS, LEATHER DRESSINGS, TEXTILE SPECIALTIES, POLISHES, CLEANING COMPOUNDS, SO-CALLED SOL OILS; INGREDIENT OF DIURETIC PAMABROM

Fabricated Metal Product Manufacturing

1-Propanol, 2-amino-2-methyl-: ACTIVE