Methyl iodide → 5-ethyl-6-methylthio-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
反応式
[K].[CH2:2]([N:4]1[C:9](=[O:10])[C:8]2[CH:11]=[N:12][NH:13][C:7]=2[N:6]=[C:5]1[SH:14])[CH3:3].[CH3:15]I>CN(C=O)C>[CH2:2]([N:4]1[C:9](=[O:10])[C:8]2[CH:11]=[N:12][NH:13][C:7]=2[N:6]=[C:5]1[S:14][CH3:15])[CH3:3]参加物
4
実験手順
To a solution of 5-ethyl-6-mercapto-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one potassium (5.0 g) in DMF (40 ml) was added methyl iodide (3.65 g) and the mixture was stirred for 1 hour. This reaction mixture was concentrated and the residue was diluted with water. The resulting crystals were collected by filtration and rinsed with water to provide 5-ethyl-6-methylthio-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one as colorless solid (2.908 g).
後処理
- concentrationThis reaction mixture was concentrated
- additionthe residue was diluted with water
- filtrationThe resulting crystals were collected by filtration
- washrinsed with water
出典と根拠
- ORDレコード
- ord-ed8c2ba196554693b96af0a07ebe6175
- 出典データセット
- uspto-grants-1998_05
- 特許番号
- US05753664
反応ノート
読み込み中…