2-[4-(4-acetoxybenzoyl) benzylthio]-3-methylthieno[3,2-d]pyrimidin-4(3H)-one → 2-[4-(4-hydroxybenzoyl)benzylthio]-3-methylthieno[3,2-d]pyrimidin-4(3H)-one

HRID 1291345ノート

反応式

HRID 1291345 の反応式
C([O:4][C:5]1[CH:31]=[CH:30][C:8]([C:9]([C:11]2[CH:29]=[CH:28][C:14]([CH2:15][S:16][C:17]3[N:18]([CH3:27])[C:19](=[O:26])[C:20]4[S:25][CH:24]=[CH:23][C:21]=4[N:22]=3)=[CH:13][CH:12]=2)=[O:10])=[CH:7][CH:6]=1)(=O)C.[OH-].[Na+].O>C1COCC1>[OH:4][C:5]1[CH:31]=[CH:30][C:8]([C:9]([C:11]2[CH:29]=[CH:28][C:14]([CH2:15][S:16][C:17]3[N:18]([CH3:27])[C:19](=[O:26])[C:20]4[S:25][CH:24]=[CH:23][C:21]=4[N:22]=3)=[CH:13][CH:12]=2)=[O:10])=[CH:7][CH:6]=1

参加物

4

反応物 2

HCID 189192362-[4-(4-acetoxybenzoyl) benzylthio]-3-methylthieno[3,2-d]pyrimidin-4(3H)-oneHCID 23719242Sodium hydroxide--water (1/1/1)

生成物 1

HCID 189189232-[4-(4-hydroxybenzoyl)benzylthio]-3-methylthieno[3,2-d]pyrimidin-4(3H)-one収率 101.2%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 2-[4-(4-acetoxybenzoyl) benzylthio]-3-methylthieno[3,2-d]pyrimidin-4(3H)-one (3.51 g) in THF (20 ml) was added 1N-sodium hydroxide/water (10 ml) and the mixture was stirred at room temperature for 30 minutes. This reaction mixture was concentrated, the residue was dissolved in water, and 1N-hydrochloric acid was added. The resulting crystals were collected by filtration, rinsed with water, and dried to provide the title compound as colorless solid (3.22 g).

後処理

  1. concentrationThis reaction mixture was concentrated
  2. dissolutionthe residue was dissolved in water
  3. addition1N-hydrochloric acid was added
  4. filtrationThe resulting crystals were collected by filtration
  5. washrinsed with water
  6. customdried

出典と根拠

ORDレコード
ord-ad72acb3032f4514bc942a9b1a7568b9
出典データセット
uspto-grants-1998_05
特許番号
US05753664

反応ノート

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