Trifluoroacetic acid → 2-Hydrazinyl-2-methylpropan-1-ol
反応式
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].C(OC([NH:15][NH:16][C:17]([CH3:21])([CH3:20])[CH2:18][OH:19])=O)(C)(C)C>ClCCl>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[NH:16]([C:17]([CH3:21])([CH3:20])[CH2:18][OH:19])[NH2:15].[NH:16]([C:17]([CH3:21])([CH3:20])[CH2:18][OH:19])[NH2:15]参加物
5
実験手順
Trifluoroacetic acid (4 mL) was added to a solution of N′-(2-hydroxy-1,1-dimethyl-ethyl)-hydrazinecarboxylic acid tert-butyl ester (490 mg, 2.4 mmol) in dichloromethane (4 mL). The mixture was stirred at room temperature for 1 h. The reaction mixture was concentrated in vacuo to give the trifluoroacetic acid salt of 2-hydrazino-2-methyl-propan-1-ol (520 mg, quantitative) which was used without further purification.
後処理
- concentrationThe reaction mixture was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-bdd69f3b39f54f018881a4e5ad070709
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07728029B2
反応ノート
読み込み中…