Hydrochloric Acid → 1-methyl-1H-imidazole-5-carboxylic acid

HRID 1292125ノート

反応式

HRID 1292125 の反応式
[CH3:1][N:2]1[C:6]([C:7]([O:9]CC)=[O:8])=[CH:5][N:4]=[CH:3]1.[OH-].[Na+].Cl>C(O)C>[CH3:1][N:2]1[C:6]([C:7]([OH:9])=[O:8])=[CH:5][N:4]=[CH:3]1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 18914307Ethyl 1-methyl-1H-imidazole-5-carboxylate

生成物 1

HCID 27735071-methyl-1H-imidazole-5-carboxylic acid収率 68.7%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 1.5 g of ethyl 1-methyl-5-imidazolecarboxylate, 5 mL of ethanol and 5 mL of 10% NaOH was stirred at room temperature for 12 h. The mixture was acidified to pH 2 with conc. HCl, diluted with 10 mL of ice water. The precipitated product was collected by filtration in 2 crops. Drying under vacuum gave 843 mg of 1-methyl-5-imidazolecarboxylic acid as a white solid.

後処理

  1. filtrationThe precipitated product was collected by filtration in 2 crops
  2. customDrying under vacuum

出典と根拠

ORDレコード
ord-15ac412d04984f3483b5778571b9ea32
出典データセット
uspto-grants-1998_05
特許番号
US05756508

反応ノート

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