Acetic Acid → N-Acetyl-L-proline

HRID 1292328

反応式

HRID 1292328 の反応式
[S-][C:2]#[N:3].[NH4+].[C:5]([OH:8])(=[O:7])[CH3:6].F[C:10](F)(F)[C:11]([OH:13])=O.[C:16](OC(=O)C)(=O)[CH3:17]>C(N(CC)CC)C>[C:11]([N:3]1[CH2:2][CH2:17][CH2:16][C@H:6]1[C:5]([OH:8])=[O:7])(=[O:13])[CH3:10]

参加物

6

反応物 4

HCID 176Acetic AcidHCID 6422Trifluoroacetic acidHCID 7918Acetic AnhydrideHCID 15666Ammonium thiocyanate

生成物 1

HCID 66141N-Acetyl-L-proline

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒

実験手順

ammonium thiocyanate (BDH, Analar), Aristar acetic acid (BDH), eptide synthesis grades of trifluoroacetic acid and acetic anhydride (Applied Biosystems) were used without further purification. Reagents for amino acid analysis of phenylthiocarbamyl amino acids were all of the highest possible purity (Inglis et al Biochem. Biophys. Methods 15:249, 1988). Pierce 6M constant boiling HC1 and Analar phenol (BDH) were used for hydrolysis and N,N-diisopropylethylamine (DIEA, Peptide Synthesis Grade, Applied Biosystems) replaced triethylamine in the drying reagent and in the coupling buffer.

後処理

  1. customwere used without further purification
  2. customand Analar phenol (BDH) were used for hydrolysis and N,N-diisopropylethylamine (DIEA, Peptide Synthesis Grade, Applied Biosystems)

出典と根拠

ORDレコード
ord-34e412f94b714d90839c31b45566e546
出典データセット
uspto-grants-1998_05
特許番号
US05756667

関連ノート

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