Sulfuric acid magnesium salt (1:1) → 2-Chloroquinoline-3,4-diamine

HRID 1292486

反応式

HRID 1292486 の反応式
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([Cl:12])[C:3]=1[N+:13]([O-])=O.S([O-])([O-])(=O)=O.[Mg+2].[H][H]>[Pt].C(OCC)(=O)C>[NH2:13][C:3]1[C:4]([Cl:12])=[N:5][C:6]2[C:11]([C:2]=1[NH2:1])=[CH:10][CH:9]=[CH:8][CH:7]=2

参加物

6

反応物 3

HCID 24083Sulfuric acid magnesium salt (1:1)HCID 218980422-Chloro-3-nitroquinolin-4-amineHCID 178418361HCID 178418361、化合物

生成物 1

HCID 218980332-Chloroquinoline-3,4-diamine

試薬・触媒・溶媒 2

HCID 23939Platinum触媒HCID 8857Ethyl Acetate溶媒

実験手順

4-amino-2-chloro-3-nitroquinoline (5 g, 0.0224 mol) was combined with ethyl acetate (300 mL), magnesium sulfate (1 g), and 5% Pt/C (0.5 g). The mixture was hydrogenerated on a Parr apparatus until no further uptake of hydrogen was observed. The resulting mixture was filtered and the solvent was removed at reduced pressure to afford a tan solid product 3,4-diamino-2-chloroquinoline.

後処理

  1. filtrationThe resulting mixture was filtered
  2. customthe solvent was removed at reduced pressure

出典と根拠

ORDレコード
ord-730adb343bd2426286b7385e67f129d1
出典データセット
uspto-grants-1998_05
特許番号
US05756747

関連ノート

読み込み中…