4-(3,4-Dichlorophenoxy)piperidine → Ammonia

HRID 1292754ノート

反応式

HRID 1292754 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:12]=[CH:13][C:14]=1[Cl:15])[O:5][CH:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1.CS(O[CH2:21][CH:22]1[O:27][CH2:26][CH2:25][N:24]([C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[CH2:23]1)(=O)=O>C(#N)C>[NH3:9].[Cl:1][C:2]1[CH:3]=[C:4]([CH:12]=[CH:13][C:14]=1[Cl:15])[O:5][CH:6]1[CH2:11][CH2:10][N:9]([CH2:21][CH:22]2[O:27][CH2:26][CH2:25][N:24]([C:28]([O:30][C:31]([CH3:32])([CH3:34])[CH3:33])=[O:29])[CH2:23]2)[CH2:8][CH2:7]1

参加物

5

反応物 2

HCID 37320424-(3,4-Dichlorophenoxy)piperidineHCID 57791474Tert-butyl 2-(((methylsulfonyl)oxy)methyl)morpholine-4-carboxylate

生成物 2

HCID 222AmmoniaHCID 17974804tert-Butyl 2-{[4-(3,4-dichlorophenoxy)piperidin-1-yl}methyl]morpholine-4-carboxylate

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

To a solution of the product from Example 1, Step (b) dissolved in acetonitrile (12 ml) was added the product of Example 2, Step (a). The mixture was refluxed for 12 hrs and the solvents were evaporated. Purification by flash chromatography (silica) eluting with dichloromethane: methanol: NH3 (aq) (2:98:0.1) gave the sub-title compound as an oil (1.9 g).

後処理

  1. temperatureThe mixture was refluxed for 12 hrs
  2. customthe solvents were evaporated
  3. customPurification by flash chromatography (silica)
  4. washeluting with dichloromethane

出典と根拠

ORDレコード
ord-035fcec48b814741adcef02eb7c64b74
出典データセット
uspto-grants-2007_07
特許番号
US07238691B2

反応ノート

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