Thionyl Chloride → 5-Chloromethyl-4-methoxy-6-trifluoromethylpyrimidine
反応式
S(Cl)([Cl:3])=O.[CH3:5][O:6][C:7]1[C:12]([CH2:13]O)=[C:11]([C:15]([F:18])([F:17])[F:16])[N:10]=[CH:9][N:8]=1>>[Cl:3][CH2:13][C:12]1[C:7]([O:6][CH3:5])=[N:8][CH:9]=[N:10][C:11]=1[C:15]([F:18])([F:17])[F:16]参加物
3
実験手順
1.19 g (10.1 mmoles) of thionyl chloride was added, at room temperature, to a solution of 0.42 g (2.02 mmoles) of (4-methoxy-6-trifluoromethylpyrimidin-5-yl)-methanol. The mixture was stirred for 3 hours to give rise to a reaction. After confirmation of the completion of the reaction, the reaction mixture was subjected to vacuum distillation to remove the solvent contained therein, to obtain 0.45 g (yield: quantitative) of 5-chloromethyl-4-methoxy-6-trifluoromethylpyrimidine.
後処理
- customto give rise
- customto a reaction
- customAfter confirmation of the completion of the reaction
- distillationthe reaction mixture was subjected to vacuum distillation
- customto remove the solvent
出典と根拠
- ORDレコード
- ord-e97c5dedc801415ab7c1630c28cbe6ce
- 出典データセット
- uspto-grants-2007_07
- 特許番号
- US07238689B2
反応ノート
読み込み中…