Ammonia → 2-Chloro-6-(2,4-difluoro-phenoxy)-quinazolin-4-ylamine

HRID 1292861

反応式

HRID 1292861 の反応式
[Cl:1][C:2]1[N:11]=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([O:13][C:14]3[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=3[F:21])[CH:8]=2)[N:3]=1.[NH3:22]>>[Cl:1][C:2]1[N:11]=[C:10]([NH2:22])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([O:13][C:14]3[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=3[F:21])[CH:8]=2)[N:3]=1

参加物

3

反応物 2

HCID 222AmmoniaHCID 588201952,4-Dichloro-6-(2,4-difluoro-phenoxy)-quinazoline

生成物 1

HCID 589051302-Chloro-6-(2,4-difluoro-phenoxy)-quinazolin-4-ylamine

実験手順

Compound (1F) (21 g, 0.06 mol) was suspended in ammonia (100 mL of 2.0 M solution in MeOH) and the solution formed after 30 min was stirred at room temperature for 18 h. The precipitate was filtered, the concentrated filtrate triturated with EtOAc, and the organic layers were combined to yield 21.5 g of 2-chloro-6-(2,4-difluorophenoxy)-quinazolin-4-ylamine (1G).

後処理

  1. customthe solution formed after 30 min
  2. filtrationThe precipitate was filtered
  3. customthe concentrated filtrate triturated with EtOAc

出典と根拠

ORDレコード
ord-9a55840aab77422bbbf1d8a693a522b8
出典データセット
uspto-grants-2007_07
特許番号
US07238698B2

関連ノート

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