Ethanol → 4-Tetradecylpyrrole-2-carboxylic acid

HRID 129337ノート

反応式

HRID 129337 の反応式
[OH-].[Na+].C(O)C.[CH2:6]([C:20]1[CH:21]=[C:22]([C:25]([O:27]C)=[O:26])[NH:23][CH:24]=1)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19]>O>[CH2:6]([C:20]1[CH:21]=[C:22]([C:25]([OH:27])=[O:26])[NH:23][CH:24]=1)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19]

参加物

5

反応物 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 19371041Methyl 4-tetradecylpyrrole-2-carboxylate

生成物 1

HCID 150232964-Tetradecylpyrrole-2-carboxylic acid収率 95%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution (1 ml) of 2N sodium hydroxide was added to an ethanol solution (5 ml) of 0.22 g (0.69 mmol) of methyl 4-tetradecylpyrrole-2-carboxylate prepared in Example 9 and heated under reflux for 13 hours. Water was added to the resulting mixture, and then washed with ether. After acidifying the aqueous layer with hydrochloric acid, the mixture was extracted with ether and dried over anhydrous magnesium sulfate. The removal of the solvent afforded 0.19 g (95% yield) of 4-tetradecylpyrrole-2-carboxylic acid, m.p. 148°-150 ° C.

後処理

  1. temperatureheated
  2. temperatureunder reflux for 13 hours
  3. washwashed with ether
  4. extractionthe mixture was extracted with ether
  5. dry with materialdried over anhydrous magnesium sulfate
  6. customThe removal of the solvent

出典と根拠

ORDレコード
ord-86a7408f747c4012a9cd394f1cdebc6e
出典データセット
uspto-grants-1995_11
特許番号
USRE035096

反応ノート

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