4-Cyclopentyloxydibenzo[b,d]furan-1-carbaldehyde → 4-Hydroxy dibenzo[b,d]furan-1-carbaldehyde
反応式
C1([O:6][C:7]2[C:12]3[O:13][C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=4[C:11]=3[C:10]([CH:20]=[O:21])=[CH:9][CH:8]=2)CCCC1>Br.C(O)(=O)C>[OH:6][C:7]1[C:12]2[O:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[C:11]=2[C:10]([CH:20]=[O:21])=[CH:9][CH:8]=1参加物
4
実験手順
Intermediate 18 was heated in HBr (30-33%) in glacial acetic acid (25 ml) at 50° C. for 7-8 h The reaction contents were poured in ice-water and extracted with ethyl acetate. The organic layer was washed with saturated sodium bicarbonate, and extracted with 10% sodium hydroxide (3×25 ml) solution. The aqueous layer was acidified with conc. HCl to give a white precipitate which was filtered and air dried to obtain the crude product as a white solid (3.2 gm).
後処理
- customThe reaction contents
- extractionextracted with ethyl acetate
- washThe organic layer was washed with saturated sodium bicarbonate
- extractionextracted with 10% sodium hydroxide (3×25 ml) solution
- customto give a white precipitate which
- filtrationwas filtered
- customair dried
出典と根拠
- ORDレコード
- ord-546a47de5d0845de85c1bfa0f309df12
- 出典データセット
- uspto-grants-2007_07
- 特許番号
- US07238725B2
反応ノート
読み込み中…