Ethyl ketone → ethyl 5-(4,5-dimethoxy-2-nitrobenzoyl)-2-(3-methoxypentan-3-yl)-2H-1,2,3-triazole-4-carboxylate
反応式
O.[C:2]1(C)[CH:7]=[CH:6]C(S(O)(=O)=O)=[CH:4][CH:3]=1.CC[C:15](=[O:18])CC.C(OC)(OC)OC.[CH3:26][O:27][C:28]1[C:45]([O:46][CH3:47])=[CH:44][C:31]([C:32]([C:34]2[NH:38][N:37]=[N:36][C:35]=2[C:39]([O:41][CH2:42][CH3:43])=[O:40])=[O:33])=[C:30]([N+:48]([O-:50])=[O:49])[CH:29]=1>C(Cl)Cl.C(N(CC)CC)C>[CH3:26][O:27][C:28]1[C:45]([O:46][CH3:47])=[CH:44][C:31]([C:32]([C:34]2[C:35]([C:39]([O:41][CH2:42][CH3:43])=[O:40])=[N:36][N:37]([C:2]([O:18][CH3:15])([CH2:7][CH3:6])[CH2:3][CH3:4])[N:38]=2)=[O:33])=[C:30]([N+:48]([O-:50])=[O:49])[CH:29]=1参加物
7
反応物 4
生成物 1
試薬・触媒・溶媒 2
実験手順
p-Toluenesulfonic acid monohydrate (20 mg) was added to a solution of 3-pentanone (3.1 ml) and trimethyl orthoformate (3.3 ml) in methylene chloride (10 ml). The mixture was heated for one hr with stirring. This solution (4 ml) was added to a solution of ethyl 5-(4,5-dimethoxy-2-nitrobenzoyl)-1H-1,2,3-triazole-4-carboxylate (Synthesis Example 2) (140 mg) in methylene chloride (2 ml). The mixture was stirred at room-temperature for one hr, and triethylamine (0.05 ml) was then added thereto. The mixture was post-treated by a conventional method and subjected to separation and purification to give ethyl 5-(4,5-dimethoxy-2-nitrobenzoyl)-2-(3-methoxypentan-3-yl)-2H-1,2,3-triazole-4-carboxylate (140 mg, 78%) as a yellow powder.
後処理
- temperatureThe mixture was heated for one hr
- stirringThe mixture was stirred at room-temperature for one hr
- additionThe mixture was post-treated by a conventional method
- customsubjected to separation and purification
出典と根拠
- ORDレコード
- ord-0d1c6bb3405e44ea86a02dfee8548b2f
- 出典データセット
- uspto-grants-2007_07
- 特許番号
- US07238812B2
反応ノート
読み込み中…