4-Aminophenol → N-[4-(3-Amino-4-nitrophenoxy)phenyl]acetamide

HRID 1294052ノート

反応式

HRID 1294052 の反応式
[N+:1]([C:4]1[CH:17]=[CH:16][C:7]([O:8][C:9]2[CH:15]=[CH:14][C:12]([NH2:13])=[CH:11][CH:10]=2)=[CH:6][CH:5]=1)([O-:3])=[O:2].[N+](C1C=C[C:24]([O:25]C2C=CC(N)=C([N+]([O-])=O)C=2)=[CH:23]C=1)([O-])=O.[NH2:38]C1C=CC(O)=CC=1.C([S-])#N.[K+].BrBr>>[C:24]([NH:13][C:12]1[CH:14]=[CH:15][C:9]([O:8][C:7]2[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[C:17]([CH:16]=2)[NH2:38])=[CH:10][CH:11]=1)(=[O:25])[CH3:23]

参加物

6

反応物 5

HCID 4034-AminophenolHCID 24408BromineHCID 802514-(4-Nitrophenoxy)benzenamineHCID 516872Potassium thiocyanateHCID 12032722Benzenamine, 2-nitro-4-(4-nitrophenoxy)-

生成物 1

HCID 13705240N-[4-(3-Amino-4-nitrophenoxy)phenyl]acetamide

実験手順

Compounds of Formula I, wherein D is CH, T is CH, M is C, Q is S, and q is 0, can be prepared according to the synthetic sequence shown in Scheme 7 and further detailed in the Examples section following. 4-(4-Nitrophenoxy)aniline (2), derived from (1) and 4-aminophenol, was cyclized with KSCN and Br2 in the presence of acid to provide thiazole (3). Subsequent reaction with ClCO2Me or butylisocyante (BuNCO) to give (4), followed by reduction with SnCl2 to give (5) and finally coupling with isocyanate afforded (6).

後処理

  1. customcan be prepared

出典と根拠

ORDレコード
ord-4814e6921c6e408d97e6a6e8c932b07a
出典データセット
uspto-grants-2007_07
特許番号
US07238813B2

反応ノート

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