Methyl 2-(2-benzyloxy-5-ethoxyphenyl)acetate → Methyl 2-(5-ethoxy-2-hydroxyphenyl)acetate

HRID 1294130ノート

反応式

HRID 1294130 の反応式
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][CH3:17])=[CH:11][C:10]=1[CH2:18][C:19]([O:21][CH3:22])=[O:20])C1C=CC=CC=1>[C].[Pd].O1CCCC1>[OH:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][CH3:17])=[CH:11][C:10]=1[CH2:18][C:19]([O:21][CH3:22])=[O:20]

参加物

4

反応物 1

HCID 17861303Methyl 2-(2-benzyloxy-5-ethoxyphenyl)acetate

生成物 1

HCID 17861247Methyl 2-(5-ethoxy-2-hydroxyphenyl)acetate収率 73.2%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of methyl 2-(2-benzyloxy-5-ethoxyphenyl)acetate (1.60 g), 5% palladium carbon (3.0 g) and tetrahydrofuran (50 mL) was subjected to catalytic hydrogenation at room temperature and 1 atm. After filtering off the catalyst, the solvent was evaporated under reduced pressure. Hexane was added to the obtained crystals and the mixture was filtrated to give crystals (0.82 g) of methyl 2-(2-hydroxy-5-ethoxyphenyl)acetate. Recrystallization from diisopropyl ether-hexane gave pale-yellow prism crystals. melting point: 83-84° C.

後処理

  1. customwas subjected to catalytic hydrogenation at room temperature
  2. filtrationAfter filtering off the catalyst
  3. customthe solvent was evaporated under reduced pressure
  4. additionHexane was added to the obtained crystals
  5. filtrationthe mixture was filtrated

出典と根拠

ORDレコード
ord-494d51de0a744ba9b3ea26724663883b
出典データセット
uspto-grants-2007_07
特許番号
US07238716B2

反応ノート

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