Thionyl Chloride → 4-Chloromethyl-2-phenyl-5-propyloxazole

HRID 1294162ノート

反応式

HRID 1294162 の反応式
[C:1]1([C:7]2[O:8][C:9]([CH2:14][CH2:15][CH3:16])=[C:10]([CH2:12]O)[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.S(Cl)([Cl:19])=O>C1(C)C=CC=CC=1>[Cl:19][CH2:12][C:10]1[N:11]=[C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[O:8][C:9]=1[CH2:14][CH2:15][CH3:16]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 178612102-Phenyl-5-propyl-4-oxazolylmethanol

生成物 1

HCID 178613954-Chloromethyl-2-phenyl-5-propyloxazole収率 151%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

To a mixture of 2-phenyl-5-propyl-4-oxazolylmethanol (1.38 g) and toluene (100 mL) was added thionyl chloride (1.38 g) under ice-cooling, and the mixture was stirred at room temperature for 1 hr. The reaction mixture was concentrated and the residue was dissolved in ethyl acetate. The mixture was washed successively with saturated aqueous sodium hydrogencarbonate and saturated brine, dried over anhydrous magnesium sulfate, and concentrated to give 4-chloromethyl-2-phenyl-5-propyloxazole as a colorless oil (2.26 g, 99%).

後処理

  1. temperaturecooling
  2. concentrationThe reaction mixture was concentrated
  3. dissolutionthe residue was dissolved in ethyl acetate
  4. washThe mixture was washed successively with saturated aqueous sodium hydrogencarbonate and saturated brine
  5. dry with materialdried over anhydrous magnesium sulfate
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-45e9cf638f1847c484d57469216781e0
出典データセット
uspto-grants-2007_07
特許番号
US07238716B2

反応ノート

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