Lithium Hydroxide → 2-(3-Bromophenyl)-2-methylpropanoic acid
反応式
[Br:1][C:2]1[CH:3]=[C:4]([C:8]([CH3:14])([CH3:13])[C:9]([O:11]C)=[O:10])[CH:5]=[CH:6][CH:7]=1.[Li+].[OH-]>C1COCC1.CO>[Br:1][C:2]1[CH:3]=[C:4]([C:8]([CH3:14])([CH3:13])[C:9]([OH:11])=[O:10])[CH:5]=[CH:6][CH:7]=1参加物
4
反応条件
- 温度
- 50 °C
実験手順
To a Solution of ester from step 1 in THF-MeOH (4:1, 0.5M) was added LiOH (3 eq, 2M) and the mixture was stirred at 50° C. for 1 h. The organic solvent evaporated, aqueous was acidified with HCl 1N and the acid extracted with EtOAc (3×). The organic was washed with brine, dried and solvent evaporated to afford the acid.
後処理
- customThe organic solvent evaporated
- extractionthe acid extracted with EtOAc (3×)
- washThe organic was washed with brine
- customdried
- customsolvent evaporated
- customto afford the acid
出典と根拠
- ORDレコード
- ord-b0bd264326d744088213f44caacdb57d
- 出典データセット
- uspto-grants-2007_07
- 特許番号
- US07238706B2
反応ノート
読み込み中…