N-[3-fluoro-2-(hydroxyl-o-tolyl-methyl)-phenyl]-acetamide → N-[3-fluoro-2-(2-methyl-benzoyl)-phenyl]-acetamide

HRID 1294568ノート

反応式

HRID 1294568 の反応式
[F:1][C:2]1[C:3]([CH:12]([OH:20])[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[CH3:19])=[C:4]([NH:8][C:9](=[O:11])[CH3:10])[CH:5]=[CH:6][CH:7]=1>C(Cl)(Cl)Cl.[O-2].[Mn+4].[O-2]>[F:1][C:2]1[C:3]([C:12](=[O:20])[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[CH3:19])=[C:4]([NH:8][C:9](=[O:11])[CH3:10])[CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 1

HCID 69489997N-[3-fluoro-2-(hydroxyl-o-tolyl-methyl)-phenyl]-acetamide

生成物 1

HCID 69489411N-[3-fluoro-2-(2-methyl-benzoyl)-phenyl]-acetamide

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6212Chloroform溶媒

実験手順

205 mg (0.75 mmol) N-[3-fluoro-2-(hydroxyl-o-tolyl-methyl)-phenyl]-acetamide are dissolved in 9 ml chloroform, combined with 652 mg (7.5 mmol) manganese(IV)-oxide and stirred for 3 d at ambient temperature. Then excess manganese(IV)-oxide is filtered off through Celite and the solvent is eliminated in vacuo. The crude product is purified by column chromatography. The carrier material used is silica gel and the eluant used is a mixture of cyclohexane:ethyl acetate (80:20).

後処理

  1. filtrationThen excess manganese(IV)-oxide is filtered off through Celite
  2. customThe crude product is purified by column chromatography
  3. additiona mixture of cyclohexane:ethyl acetate (80:20)

出典と根拠

ORDレコード
ord-0a32ff9d21694fd790aba529c9ff32d8
出典データセット
uspto-grants-2007_07
特許番号
US07241769B2

反応ノート

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