Hydrochloric Acid → (2-Amino-6-fluoro-phenyl)-o-tolyl-methanone

HRID 1294569ノート

反応式

HRID 1294569 の反応式
[F:1][C:2]1[C:3]([C:12](=[O:20])[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[CH3:19])=[C:4]([NH:8]C(=O)C)[CH:5]=[CH:6][CH:7]=1.Cl.O.C(=O)([O-])[O-].[Na+].[Na+]>C(O)C>[NH2:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[C:3]=1[C:12]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[CH3:19])=[O:20]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 10340Sodium CarbonateHCID 69489411N-[3-fluoro-2-(2-methyl-benzoyl)-phenyl]-acetamide

生成物 1

HCID 58906377(2-Amino-6-fluoro-phenyl)-o-tolyl-methanone

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
70 °C

実験手順

142 mg (0.52 mmol) N-[3-fluoro-2-(2-methyl-benzoyl)-phenyl]-acetamide are dissolved in 2 ml of ethanol, combined with 2 ml of conc. hydrochloric acid and stirred for 4 h at 70° C. Then the reaction mixture is stirred into 30 ml dist. water, adjusted to pH 7 with sodium carbonate and extracted three times with 10 ml of ethyl acetate. Then the organic phase is dried with MgSO4 and the solvent is eliminated in vacuo.

後処理

  1. stirringThen the reaction mixture is stirred into 30 ml dist
  2. extractionextracted three times with 10 ml of ethyl acetate
  3. dry with materialThen the organic phase is dried with MgSO4

出典と根拠

ORDレコード
ord-fe5e17c8541246c4a9fdfc9f3fed9baa
出典データセット
uspto-grants-2007_07
特許番号
US07241769B2

反応ノート

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