Imidazole → 1-[2-(4-methylphenyl)ethyl]-1H-imidazole

HRID 129461ノート

反応式

HRID 129461 の反応式
CS(O[CH2:6][CH2:7][C:8]1[CH:13]=[CH:12][C:11]([CH3:14])=[CH:10][CH:9]=1)(=O)=O.[NH:15]1[CH:19]=[CH:18][N:17]=[CH:16]1.C(=O)([O-])[O-].[K+].[K+]>O1CCCC1>[CH3:14][C:11]1[CH:12]=[CH:13][C:8]([CH2:7][CH2:6][N:15]2[CH:19]=[CH:18][N:17]=[CH:16]2)=[CH:9][CH:10]=1

参加物

5

反応物 3

HCID 795ImidazoleHCID 11430Potassium CarbonateHCID 12942077HCID 12942077、化合物

生成物 1

HCID 110305321-[2-(4-methylphenyl)ethyl]-1H-imidazole収率 83%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of 28.9 g of 2-(4-methylphenyl)ethanol methanesulfonate, 18.6 g of 1H-imidazole, 22.7 g of potassium carbonate and 600 ml of tetrahydrofuran was stirred for 18 hours at reflux temperature. After cooling, the reaction mixture was evaporated and the residue was taken up in water and extracted with 4-methyl-2-pentanone. The extract was dried, filtered and evaporated and the residue was destilled (13.3 Pa; 120° C.), yielding 20.1 g (83.0%) of 1-[2-(4-methylphenyl)ethyl]-1H-imidazole (interm. 6).

後処理

  1. temperatureat reflux temperature
  2. temperatureAfter cooling
  3. customthe reaction mixture was evaporated
  4. extractionextracted with 4-methyl-2-pentanone
  5. customThe extract was dried
  6. filtrationfiltered
  7. customevaporated
  8. custom(13.3 Pa; 120° C.)

出典と根拠

ORDレコード
ord-f5becf5be765473c9021c08a83365753
出典データセット
uspto-grants-1995_11
特許番号
US05468743

反応ノート

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