Piperazine → 5-Chloro-2-piperazin-1-yl-benzothiazole

HRID 1294778ノート

反応式

HRID 1294778 の反応式
Cl[C:2]1[S:3][C:4]2[CH:10]=[CH:9][C:8]([Cl:11])=[CH:7][C:5]=2[N:6]=1.[NH:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1.C(N(CC)CC)C>O1CCCC1>[Cl:11][C:8]1[CH:9]=[CH:10][C:4]2[S:3][C:2]([N:12]3[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]3)=[N:6][C:5]=2[CH:7]=1

参加物

5

反応物 3

HCID 4837PiperazineHCID 8471TriethylamineHCID 133148162,5-Dichloro-1,3-benzothiazole

生成物 1

HCID 113342655-Chloro-2-piperazin-1-yl-benzothiazole

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
160 °C

実験手順

A mixture of 0.49 mmol 2,5-dichlorobenzothiazole (CA=[2941-48-2]), 1.47 mmol of piperazine and 1.47 mmol of triethylamine in 5 ml of tetrahydrofuran in a sealed tube was heated at 160° C. for 5 min under microwave irradiation. The reaction mixture was concentrated, and the residue was purified by chromatography (SiO2, methanol/dichloromethane) to yield the title compound as a white solid.

後処理

  1. concentrationThe reaction mixture was concentrated
  2. customthe residue was purified by chromatography (SiO2, methanol/dichloromethane)

出典と根拠

ORDレコード
ord-914b2024f4494174a56d526392463f07
出典データセット
uspto-grants-2007_07
特許番号
US07241761B2

反応ノート

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