Isopropyl iodide → 7-fluoro-1-isopropyl-3-(4-methoxyphenyl)-1H-indazole

反応式

[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][N:8]=[C:7]2[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=1.[H-].[Na+].I[CH:22]([CH3:24])[CH3:23]>>[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[N:9]([CH:22]([CH3:24])[CH3:23])[N:8]=[C:7]2[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=1

参加物

反応物 3

HCID 6362Isopropyl iodide

HCID 24758Sodium hydride

HCID 178489142HCID 178489142、化合物

生成物 1

HCID 694270987-fluoro-1-isopropyl-3-(4-methoxyphenyl)-1H-indazole収率 61.9%

実験手順

Prepared according to Method D step B from 7-fluoro-3-(4-methoxyphenyl)-1H-indazole (0.121 g, 0.5 mmol), sodium hydride (60% in oil, 0.024 g, 0.6 mmol) and 2-iodopropane (0.10 mL, 1.0 mmol) to give the title compound (0.088 g) as a white solid.

後処理

customPrepared

出典と根拠

ORDレコード: ord-6f89f05413d4483fa141f08f1fe705d3
出典データセット: uspto-grants-2007_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07241791B2

反応ノート

読み込み中…