Isobutyl iodide → 3-(2,4-dimethoxyphenyl)-7-fluoro-2-isobutyl-2H-indazole

反応式

[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[CH:5][C:4]=1[C:11]1[C:19]2[C:14](=[C:15]([F:20])[CH:16]=[CH:17][CH:18]=2)[NH:13][N:12]=1.[H-].[Na+].I[CH2:24][CH:25]([CH3:27])[CH3:26]>>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[CH:5][C:4]=1[C:11]1[N:12]([CH2:24][CH:25]([CH3:27])[CH3:26])[N:13]=[C:14]2[C:19]=1[CH:18]=[CH:17][CH:16]=[C:15]2[F:20]

参加物

反応物 3

HCID 10556Isobutyl iodide

HCID 24758Sodium hydride

HCID 1784891453-(2,4-dimethoxyphenyl)-7-fluoro-1H-indazole

生成物 1

HCID 688841233-(2,4-dimethoxyphenyl)-7-fluoro-2-isobutyl-2H-indazole収率 12.7%

実験手順

Prepared according to Method D step B from 3-(2,4-dimethoxyphenyl)-7-fluoro-1H-indazole (0.300 g, 1.10 mmol), sodium hydride (60% in oil, 0.058 g, 1.50 mmol) and 1-iodo-2-methylpropane (0.23 mL, 2.00 mmol) to give the title compound (0.046 g) as a white solid.