HCID 22570297、化合物 → Methyl 3-(5-hydroxyindolyl)-2-methylpropanoate

HRID 1295116ノート

反応式

HRID 1295116 の反応式
[CH3:1][CH:2]([CH2:7][C:8]1[NH:9][C:10]2[C:15]([CH:16]=1)=[CH:14][C:13]([O:17]CC1C=CC=CC=1)=[CH:12][CH:11]=2)[C:3]([O:5][CH3:6])=[O:4]>C(O)C.[Pd]>[OH:17][C:13]1[CH:14]=[C:15]2[C:10](=[CH:11][CH:12]=1)[NH:9][C:8]([CH2:7][CH:2]([CH3:1])[C:3]([O:5][CH3:6])=[O:4])=[CH:16]2

参加物

4

反応物 1

HCID 22570297HCID 22570297、化合物

生成物 1

HCID 22570322Methyl 3-(5-hydroxyindolyl)-2-methylpropanoate収率 85%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A mixture of methyl 2-methyl-3-[5-benzyloxyindolyl]propanoate (0.18 g, 0.56 mmol), as prepared in the preceding step, 10% palladium(0) on carbon (0.018 g) in ethanol (10 mL) was stirred at ambient temperature under hydrogen (balloon) overnight (16 h). The catalyst was removed by filtration through Celite. The filtrate was concentrated to give the title compound as a light brown oil (0.11 g, 85%) which was used directly in the next reaction.

後処理

  1. customThe catalyst was removed by filtration through Celite
  2. concentrationThe filtrate was concentrated

出典と根拠

ORDレコード
ord-5053926935a34cf8afad0bbb8c7dee8e
出典データセット
uspto-grants-2007_07
特許番号
US07241789B2

反応ノート

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