Tetrahydrofuran → HCID 178499559、化合物
反応式
C([O:8][C:9]1[C:13]([CH2:14][C:15]([O:17][CH3:18])=[O:16])=[CH:12][N:11]([CH3:19])[N:10]=1)C1C=CC=CC=1.O1CCCC1>[C].[Pd].C(O)C>[OH:8][C:9]1[C:13]([CH2:14][C:15]([O:17][CH3:18])=[O:16])=[CH:12][N:11]([CH3:19])[N:10]=1参加物
5
実験手順
A mixture of methyl 3-benzyloxy-1-methyl-1H-pyrazol-4-ylacetate (12.2 g), 5% palladium-carbon (25.0 g), tetrahydrofuran (100 ml) and ethanol (100 ml) was stirred under hydrogen atmosphere for 5 hrs. Palladium-carbon was filtered off and the filtrate was concentrated to give methyl 3-hydroxy-1-methyl-1H-pyrazol-4-ylacetate (6.33 g, yield 79%) as colorless crystals. The crystals were recrystallized from tetrahydrofuran-hexane. melting point: 118–119° C.
後処理
- filtrationPalladium-carbon was filtered off
- concentrationthe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-0300f95395d24c76b164716c37219bad
- 出典データセット
- uspto-grants-2007_07
- 特許番号
- US07241785B2
反応ノート
読み込み中…