ethyl (E)-3-(3-benzyloxy-1-phenyl-1H-pyrazol-4-yl)propenoate → ethyl 3-(3-benzyloxy-1-phenyl-1H-pyrazol-4-yl)propionate
反応式
[CH2:1]([O:8][C:9]1[C:13](/[CH:14]=[CH:15]/[C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:12][N:11]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>[C].[Pd].O1CCCC1>[CH2:1]([O:8][C:9]1[C:13]([CH2:14][CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:12][N:11]([C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)[N:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1参加物
4
実験手順
A mixture of ethyl (E)-3-(3-benzyloxy-1-phenyl-1H-pyrazol-4-yl)propenoate (2.70 g), 5% palladium-carbon (3.00 g) and tetrahydrofuran (100 ml) was stirred under a hydrogen atmosphere at room temperature for 3 hrs. Palladium-carbon was filtered off and the filtrate was concentrated. The obtained crystals were collected by filtration to give ethyl 3-(3-benzyloxy-1-phenyl-1H-pyrazol-4-yl)propionate (1.78 g, yield 89%), which was then recrystallized from ethyl acetate-hexane. melting point: 123–124° C.