(3-benzyloxy-1-phenyl-1H-pyrazol-5-yl)methanol → HCID 22930766、化合物

HRID 1295276ノート

反応式

HRID 1295276 の反応式
[CH2:1]([O:8][C:9]1[CH:13]=[C:12]([CH2:14][OH:15])[N:11]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>[O-2].[O-2].[Mn+4].O1CCCC1>[CH2:1]([O:8][C:9]1[CH:13]=[C:12]([CH:14]=[O:15])[N:11]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[N:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 1

HCID 22930692(3-benzyloxy-1-phenyl-1H-pyrazol-5-yl)methanol

生成物 1

HCID 22930766HCID 22930766、化合物収率 91%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of (3-benzyloxy-1-phenyl-1H-pyrazol-5-yl)methanol (11.20 g), active manganese dioxide (30.00 g) and tetrahydrofuran (300 ml) was stirred overnight at room temperature. Insoluble material was filtered off and the filtrate was concentrated. The residue was subjected to silica gel column chromatography, and 3-benzyloxy-1-phenyl-1H-pyrazole-5-carbaldehyde (10.10 g, yield 91%) was obtained as a pale-yellow oil from a fraction eluted with ethyl acetate-hexane (1:2, volume ratio).

後処理

  1. filtrationInsoluble material was filtered off
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-152ec01c6cf24cde9281a8f9051a98cd
出典データセット
uspto-grants-2007_07
特許番号
US07241785B2

反応ノート

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