N-bromobutanimide → 6-Bromomethyl-4-methanesulfonyl-3,4-dihydro-2H-benzo[1,4]oxazine

HRID 1295558ノート

反応式

HRID 1295558 の反応式
[CH3:1][S:2]([N:5]1[C:10]2[CH:11]=[C:12]([CH3:15])[CH:13]=[CH:14][C:9]=2[O:8][CH2:7][CH2:6]1)(=[O:4])=[O:3].[Br:16]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl.[W]>[Br:16][CH2:15][C:12]1[CH:13]=[CH:14][C:9]2[O:8][CH2:7][CH2:6][N:5]([S:2]([CH3:1])(=[O:3])=[O:4])[C:10]=2[CH:11]=1

参加物

5

反応物 2

HCID 67184N-bromobutanimideHCID 694178614-Methanesulfonyl-6-methyl-3,4-dihydro-2H-benzo[1,4]oxazine

生成物 1

HCID 694200776-Bromomethyl-4-methanesulfonyl-3,4-dihydro-2H-benzo[1,4]oxazine収率 100%

試薬・触媒・溶媒 2

HCID 23964Tungsten触媒HCID 5943Carbon Tetrachloride溶媒

実験手順

4-Methanesulfonyl-6-methyl-3,4-dihydro-2H-benzo[1,4]oxazine (2.0 g, 8.8 mmol) and N-bromosuccinimide (1.88 g, 10.6 mmol) were dissolved in carbon tetrachloride (100 mL) and the mixture heated at reflux under a 250 W tungsten lamp. After 2 h the mixture was cooled to ambient temperature and filtered through Kieselguhr. The combined filtrate and washings were evaporated to dryness under reduced pressure to give the title compound (2.66 g, 100%) as a brown oil.

後処理

  1. temperaturethe mixture heated
  2. filtrationfiltered through Kieselguhr
  3. customThe combined filtrate and washings were evaporated to dryness under reduced pressure

出典と根拠

ORDレコード
ord-71b8f1b2a2374a98aba49371a4cc6918
出典データセット
uspto-grants-2007_07
特許番号
US07244726B2

反応ノート

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