Methanol → 1-Bromo-4-(dimethoxymethyl)benzene

HRID 129561

反応式

HRID 129561 の反応式
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1.[CH:10]([O-])([O-])[O:11]C.[CH3:15]O>C1(C)C=CC(S(O)(=O)=O)=CC=1>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]([O:11][CH3:10])[O:7][CH3:15])=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 887MethanolHCID 707414-BromobenzaldehydeHCID 53629101Methylorthoformate

生成物 1

HCID 6883421-Bromo-4-(dimethoxymethyl)benzene

試薬・触媒・溶媒 1

HCID 6101p-Toluenesulfonic acid触媒

実験手順

A mixture of 4-bromobenzaldehyde (21.9 g, 120 mmol), methyl orthoformate (50 mL, 457 mmol), and para-toluenesulfonic acid (0.05 g, 0.29 mmol) in 100 mL of methanol was heated under reflux for 5 hours. The solvent was removed under vacuum and distillation of the remaining residue gave 1-bromo-4-(dimethoxymethyl)benzene (2.24 g, 9.7 mmol) as a clear colorless oil.

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 5 hours
  3. customThe solvent was removed under vacuum and distillation of the remaining residue

出典と根拠

ORDレコード
ord-982932756d994372a643c2242b12ec62
出典データセット
uspto-grants-1995_11
特許番号
US05468867

関連ノート

読み込み中…