Sodium borohydride → HCID 69507792、化合物

HRID 1295737ノート

反応式

HRID 1295737 の反応式
[CH3:1][N:2]=[CH:3][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([O:10][CH2:11][S:12][CH3:13])[CH:5]=1.[BH4-].[Na+]>CCO>[CH3:1][NH:2][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([O:10][CH2:11][S:12][CH3:13])[CH:5]=1

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 69507905828242-89-3

生成物 1

HCID 69507792HCID 69507792、化合物収率 57%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
0 °C

実験手順

Compound from step 2 (3.546 g, 18.16 mmol) was dissolved in EtOH (50 mL) and cooled to 0° C. NaBH4 (859 mg, 22.70 mmol) was added and the mixture was allowed to stir for 4 h. The reaction was carefully quenched with water. The EtOH was removed in vacuo. The aqueous residue was extracted with CH2Cl2. The organic extracts were dried over Na2SO4 and concentrated in vacuo to give 2.044 g (57%) of a clear yellow oil.

後処理

  1. customThe reaction was carefully quenched with water
  2. customThe EtOH was removed in vacuo
  3. extractionThe aqueous residue was extracted with CH2Cl2
  4. dry with materialThe organic extracts were dried over Na2SO4
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-6f44ce3d52c6454cadab13845d9096b1
出典データセット
uspto-grants-2007_07
特許番号
US07244738B2

反応ノート

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