Hydrochloric Acid → Methyl 2-(3-methoxyphenylthio)phenylacetate

HRID 129593

反応式

HRID 129593 の反応式
[Na].[CH3:2][O:3][C:4]1[CH:5]=[C:6]([SH:10])[CH:7]=[CH:8][CH:9]=1.Br[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[CH2:18][C:19]([OH:21])=[O:20].Cl.[CH3:23]N(C=O)C>[Cu]Cl.CO.O>[CH3:2][O:3][C:4]1[CH:5]=[C:6]([S:10][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[CH2:18][C:19]([O:21][CH3:23])=[O:20])[CH:7]=[CH:8][CH:9]=1

参加物

9

反応物 5

HCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 849893-MethoxybenzenethiolHCID 877542-Bromophenylacetic acidHCID 5360545Sodium

生成物 1

HCID 14674865Methyl 2-(3-methoxyphenylthio)phenylacetate収率 91%

試薬・触媒・溶媒 3

HCID 62652Cuprous chloride触媒HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

A mixture of the sodium salt of 3-methoxythiophenol [prepared by treatment of 3-methoxythiophenol (2.8 g) with sodium hydroxide (0.8 g) in methanol (20 ml) followed by evaporation to dryness], 2-bromophenylacetic acid (4.3 g) and copper(I) chloride (0.4 g) in dry DMF (25 ml) was heated overnight at reflux. The reaction mixture was cooled, poured into water and acidified with dilute hydrochloric acid. The aqueous mixture was extracted with ether (×3) and the combined ether extracts were extracted in turn with dilute sodium hydroxide solution (×2). The combined aqueous hydroxide extracts were acidified with dilute hydrochloric acid and re-extracted with ether (×3). These combined ether extracts were washed with water (×3), dried and evaporated to give an orange oil (3.5 g, 96.8% by GC). The oil was treated with acidic methanol overnight at room temperature. Normal work-up afforded methyl 2-(3-methoxyphenylthio)phenylacetate (2.9 g, 91% by GC) as a yellow liquid which was used in the next stage without further purification.

後処理

  1. temperaturewas heated overnight
  2. temperatureat reflux
  3. temperatureThe reaction mixture was cooled
  4. extractionThe aqueous mixture was extracted with ether (×3)
  5. extractionthe combined ether extracts were extracted in turn with dilute sodium hydroxide solution (×2)
  6. extractionre-extracted with ether (×3)
  7. washThese combined ether extracts were washed with water (×3)
  8. customdried
  9. customevaporated
  10. customto give an orange oil (3.5 g, 96.8% by GC)

出典と根拠

ORDレコード
ord-540b33ba3e3342d4a5ec8156a8794b81
出典データセット
uspto-grants-1995_11
特許番号
US05468857

関連ノート

読み込み中…