Sodium Iodide → 6-Iodopyridine-3-carboxylic acid
反応式
[I-:1].[Na+].I.Cl[C:5]1[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[CH:7][N:6]=1>CC(C)=O>[I:1][C:5]1[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[CH:7][N:6]=1参加物
5
実験手順
A mixture of 15.962 g ((0.106 mol) of sodium iodide in 51 g (30 ml, 40 mmol) of hydriodic acid were stirred for 5 minutes. To the mixture was added 17.184 g (0.109 mol) of 6-chloro-nicotinic acid and the resulting mixture refluxed at 100-130 C.°C. for 40 hours. The dark brown mixture was then taken up in 300 ml of acetone and stirred to dissolve the excess NaI. The product was collected by suction filtration, rinsed with 100 mL in 1N NaHSO3 and dried to give the title compound as a yellow solid.
後処理
- temperaturethe resulting mixture refluxed at 100-130 C.°C
- waitfor 40 hours
- stirringstirred
- filtrationThe product was collected by suction filtration
- washrinsed with 100 mL in 1N NaHSO3
- customdried
出典と根拠
- ORDレコード
- ord-0aaa02c4385242519d249725f36a9c80
- 出典データセット
- uspto-grants-1995_11
- 特許番号
- US05468879
反応ノート
読み込み中…