(5-Benzyloxyindole-1-yl)acetic acid methyl ester → methyl (5-hydroxy-1H-indol-1-yl)acetate
反応式
[CH3:1][O:2][C:3](=[O:22])[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][C:10]([O:14]CC3C=CC=CC=3)=[CH:11][CH:12]=2)[CH:7]=[CH:6]1>C(OCC)(=O)C.C(O)C.[Pd]>[CH3:1][O:2][C:3](=[O:22])[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][C:10]([OH:14])=[CH:11][CH:12]=2)[CH:7]=[CH:6]1参加物
4
実験手順
Compound 72A (18.9 g, 64 mmol) was dissolved in 100 ml 1:1 ethyl acetate/ethanol. 200 mg 10% Pd/C was added followed by purging with hydrogen. The reaction was stirred vigorously under balloon pressure for 16 h. The reaction was filtered through Celite® and concentrated to an oil which was filtered through 0.45 uM filter to give a pale yellow oil which crystallized on standing. MS m/z 206 (M+1).
後処理
- customby purging with hydrogen
- filtrationThe reaction was filtered through Celite®
- concentrationconcentrated to an oil which
- filtrationwas filtered through 0.45 uM
- filtrationfilter
- customto give a pale yellow oil which
- customcrystallized
出典と根拠
- ORDレコード
- ord-20780514517043c3b197da62948ccf99
- 出典データセット
- uspto-grants-2007_07
- 特許番号
- US07244763B2
反応ノート
読み込み中…