Trifluoroacetic acid → 2-Amino-5-chloro-3-phenylthiophene

HRID 1296192ノート

反応式

HRID 1296192 の反応式
C([NH:8][C:9]1[S:10][C:11]([Cl:20])=[CH:12][C:13]=1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)(OC(C)(C)C)=O.FC(F)(F)C(O)=O>ClCCl.CN(C=O)C>[NH2:8][C:9]1[S:10][C:11]([Cl:20])=[CH:12][C:13]=1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

参加物

5

反応物 2

HCID 6422Trifluoroacetic acidHCID 589117542-(N-Boc-amino)-5-chloro-3-phenyl-thiophene

生成物 1

HCID 589118102-Amino-5-chloro-3-phenylthiophene

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒HCID 6344Dichloromethane溶媒

実験手順

2-(N-Boc-amino)-5-chloro-3-phenyl-thiophene (66 mg, 0.21 mmol) was treated with trifluoroacetic acid (1 ml) in dichloromethane (3 ml) at ambient temperature for 1 hr. The mixture was diluted with DMF (1 ml) and the more volatile materials removed under reduced pressure. The resulting DMF solution of 2-amino-5-chloro-3-phenylthiophene was used in the subsequent coupling step without purification.

後処理

  1. customthe more volatile materials removed under reduced pressure
  2. customThe resulting DMF solution of 2-amino-5-chloro-3-phenylthiophene was used in the subsequent coupling step without purification

出典と根拠

ORDレコード
ord-446f0741cbf64ef6a1e61270c90ca66c
出典データセット
uspto-grants-2007_07
特許番号
US07244851B2

反応ノート

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