Trifluoromethanesulfonic acid → HCID 18930391、化合物

HRID 129633ノート

反応式

HRID 129633 の反応式
[F:1][C:2]([F:8])([F:7])[S:3](O)(=O)=O.[Cl:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[NH:20][C:19]([C:21]([O:23][CH3:24])=[O:22])=[CH:18][CH:17]=2)=[CH:12][CH:11]=1.FC(F)(F)SCl>C(Cl)Cl>[Cl:9][C:10]1[CH:11]=[CH:12][C:13]([C:16]2[NH:20][C:19]([C:21]([O:23][CH3:24])=[O:22])=[CH:18][C:17]=2[S:3][C:2]([F:8])([F:7])[F:1])=[CH:14][CH:15]=1

参加物

5

反応物 3

HCID 62406Trifluoromethanesulfonic acidHCID 67900Methanesulfenyl chloride, trifluoro-HCID 18930419HCID 18930419、化合物

生成物 1

HCID 18930391HCID 18930391、化合物収率 902.7%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

反応条件

温度
-15 °C

実験手順

Trifluoromethanesulfonic acid (0.27 g, 0.001795 mol) is added to a solution of methyl 5-(p-chlorophenyl)pyrrole-2-carboxylate (4.23 g, 0.01795 mol) in methylene chloride (70 mL) at -30° C. This mixture is treated with trifluoromethylsulfenyl chloride (4.0 g, 0.0293 mol), stirred for 30 minutes at -15° C., warmed to room temperature with stirring for three hours, diluted with methylene chloride, washed with saturated sodium hydrogen carbonate solution and brine, dried over anhydrous magnesium sulfate and concentrated in vacuo to obtain the title product as an off-white solid (5.44 g, mp 133°-137° C.) which is identified by 1HNMR spectral analysis.

後処理

  1. temperaturewarmed to room temperature
  2. stirringwith stirring for three hours
  3. washwashed with saturated sodium hydrogen carbonate solution and brine
  4. dry with materialdried over anhydrous magnesium sulfate
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-c043a199ef8f4bcda0ed4527478edfd1
出典データセット
uspto-grants-1995_11
特許番号
US05468877

反応ノート

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