Hydrazine hydrate (1:1) → 4-(5-methyl-4-phenyl-1H-pyrazol-3-yl)benzene-1,3-diol

HRID 1296918ノート

反応式

HRID 1296918 の反応式
[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=O)[C:7]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[C:8]([CH3:12])[O:9]2)=[CH:4][CH:3]=1.O.[NH2:21][NH2:22]>C(O)C>[CH3:12][C:8]1[NH:22][N:21]=[C:6]([C:5]2[CH:4]=[CH:3][C:2]([OH:1])=[CH:11][C:10]=2[OH:9])[C:7]=1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 53809767-hydroxy-2-methyl-3-phenyl-4H-chromen-4-one

生成物 1

HCID 9369204-(5-methyl-4-phenyl-1H-pyrazol-3-yl)benzene-1,3-diol

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

This compounds was synthesised in the same manner as described above. 7-Hydroxy-2-methyl-3-phenyl-chromen-4-one (0.5 g, 1.70 mmol), hydrazine hydrate (5 ml), ethanol (10 ml). The quenched solution was extracted into ethyl acetate, washed (water), dried (MgSO4), and the solvent removed under vacuum to give a yellow oil which was purified by column chromatography to give 4-(5-Methyl-4-phenyl-1H-pyrazol-3-yl)-benzene-1,3-diol as an off white solid (0.37 g, 88%); Rf 0.7 Cf SM 0.8 ethyl acetate/hexane (80/20).

後処理

  1. customThis compounds was synthesised in the same manner
  2. extractionThe quenched solution was extracted into ethyl acetate
  3. washwashed (water)
  4. dry with materialdried (MgSO4)
  5. customthe solvent removed under vacuum
  6. customto give a yellow oil which
  7. customwas purified by column chromatography

出典と根拠

ORDレコード
ord-403181738b0a42d7b1a9af64ac077139
出典データセット
uspto-grants-2007_07
特許番号
US07247734B2

反応ノート

読み込み中…