2-Naphthol → Penicillin G

HRID 129703

反応式

HRID 129703 の反応式
[CH3:1][C:2]1[CH2:11][S:10][C@@H:5]2[C@H:6]([NH2:9])[C:7](=[O:8])[N:4]2[C:3]=1[C:12]([OH:14])=[O:13].[CH:15]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)C=C[C:16]=1[OH:25].[OH-].[NH4+]>O>[CH3:11][C:2]1([CH3:1])[S:10][C@@H:5]2[C@H:6]([NH:9][C:16]([CH2:15][C:24]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[O:25])[C:7](=[O:8])[N:4]2[C@H:3]1[C:12]([OH:14])=[O:13]

参加物

5

反応物 3

HCID 86632-NaphtholHCID 14923Ammonium HydroxideHCID 334987-Aminodeacetoxycephalosporanic acid

生成物 1

HCID 5904Penicillin G

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

反応条件

温度
25 °C

実験手順

The pH value of a mixture (slurry) of D-PGA.1/2H2SO4 (74.7 g, 0.375 mol), 7-ADCA (21.4 g, 0.10 mol), and 2-naphthol (10.8 g, 0.075 mol, particle size <100 μm) in approximately 300 ml of water was adjusted to 6.7 by addition of 4M ammonium hydroxide. Water was added to 400 ml followed by immobilized E. coli Penicillin G acylase prepared as described above (50 g on dry basis suspended in water to a total of 100 ml), and the mixture was stirred at 25° C.

後処理

  1. customon dry basis

出典と根拠

ORDレコード
ord-2576228db0324c0b98d3a4546f045b56
出典データセット
uspto-grants-1995_11
特許番号
US05470717

関連ノート

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