Water → 2-Methyl-2-(3-pyridyl)thiazolidine-4-carboxylic acid

HRID 129726

反応式

HRID 129726 の反応式
[C:1]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=1)(=O)[CH3:2].[NH2:10][C@H:11]([C:14]([OH:16])=[O:15])[CH2:12][SH:13].O>C(O)C>[CH3:2][C:1]1([C:4]2[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=2)[NH:10][CH:11]([C:14]([OH:16])=[O:15])[CH2:12][S:13]1

参加物

5

反応物 3

HCID 962WaterHCID 5862L-(+)-CysteineHCID 95893-Acetylpyridine

生成物 1

HCID 148815392-Methyl-2-(3-pyridyl)thiazolidine-4-carboxylic acid収率 37.8%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 3.63 g of 3-acetylpyridine, 3.63 g of L-cysteine, 25 ml of water and 25 ml of ethanol was refluxed for 24 hours. The reaction mixture was concentrated under reduced pressure, isopropanol was added to the residue, and the resultant powder was collected by filtration. Ethanol was added to the powder, the insoluble matter was filtered off, and the filtrate was concentrated to dryness. The residue was dissolved in water and adjusted to pH 6 by addition of diluted hydrochloric acid under ice cooling and stirring, and the resultant powder was collected by filtration, washed with ethanol and dried to give 2.54 g of 2-methyl-2-(3-pyridyl)thiazolidine-4- carboxylic acid.

後処理

  1. temperaturewas refluxed for 24 hours
  2. concentrationThe reaction mixture was concentrated under reduced pressure, isopropanol
  3. additionwas added to the residue
  4. filtrationthe resultant powder was collected by filtration
  5. additionEthanol was added to the powder
  6. filtrationthe insoluble matter was filtered off
  7. concentrationthe filtrate was concentrated to dryness
  8. dissolutionThe residue was dissolved in water
  9. additionadjusted to pH 6 by addition of diluted hydrochloric acid under ice cooling
  10. filtrationthe resultant powder was collected by filtration
  11. washwashed with ethanol
  12. customdried

出典と根拠

ORDレコード
ord-d9856abc93b2451cbf7466012acd1937
出典データセット
uspto-grants-1995_11
特許番号
US05470851

関連ノート

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