3-Pyridinecarboxaldehyde → (2R,4S)-2-(pyridin-3-yl)-1,3-thiazolidine-4-carboxylic acid

関与物質

反応手順

A solution of 1.07 g of pyridine-3-aldehyde and 1.21 g of D-cysteine in 60% v/v aqueous ethanol was heated under reflux for 4 hours. The mixture was cooled to room temperature and the resulting solid material was removed by filtration. The filtrate was concentrated by evaporation under reduced pressure, and 5 ml of ethanol were added to the resulting residue. Collecting the precipitated crystals by filtration gave 1.13 g (yield 54%) of the title compound, melting at 138°-139° C.

情報源と証拠