Benzhydrylpiperazine → HCID 19370347、化合物
反応式
CS(O[CH2:6][CH2:7][N:8]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH3:9])(=O)=O.[C:15]1([CH:21]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[N:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[C:28]1([CH:21]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[N:22]2[CH2:23][CH2:24][N:25]([CH2:6][CH2:7][N:8]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH3:9])[CH2:26][CH2:27]2)[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1参加物
3
反応条件
- 温度
- 80 °C
実験手順
A mixture of 0.23 g of 2-(N-ethoxycarbonyl-N-methylamino)ethyl methanesulfonate (prepared as described in Preparation 34') and 0.26 g of 4-diphenylmethylpiperazine was stirred at 80° C. for 5 hours. At the end of this time, the mixture was purified by column chromatography through silica gel, using a 20:1 by volume mixture of ethyl acetate and ethanol as the eluent, to give 0.25 g (yield 64%) of the title compound as an oil.
後処理
- customprepared
- customAt the end of this time, the mixture was purified by column chromatography through silica gel