Methyl (4-cyanophenyl)acetate → Methyl 4-aminomethylphenylacetate
反応式
[CH3:1][O:2][C:3](=[O:13])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]#[N:12])=[CH:7][CH:6]=1>[OH-].[Pd+2].[OH-].[OH-].[NH4+].CO>[CH3:1][O:2][C:3](=[O:13])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][NH2:12])=[CH:7][CH:6]=1参加物
4
実験手順
Palladium hydroxide (Pearlman's catalyst, 1.04 g) was added to a solution of conc. aq. ammonium hydroxide:methanol (1:4) (50 mL) in a Parr flask. (4-Cyano-phenyl)-acetic acid methyl ester (1.00 g) was added to the solution. The Parr flask was then shaken for 20 min under hydrogen (50 psi). The reaction mixture was filtered (nylon 66) and the filtrate concentrated in vacuo to yield crude title compound (1.22 g).
後処理
- filtrationThe reaction mixture was filtered (nylon 66)
- concentrationthe filtrate concentrated in vacuo
出典と根拠
- ORDレコード
- ord-ffe9657b1a10466a9d113f8bb333bf5b
- 出典データセット
- uspto-grants-2007_07
- 特許番号
- US07250518B2
反応ノート
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