Hydrogen Bromide → 16-Bromohexadecanoic acid

HRID 130280

反応式

HRID 130280 の反応式
O[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]([OH:19])=[O:18].[BrH:20]>C(O)(=O)C>[Br:20][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]([OH:19])=[O:18]

参加物

4

反応物 2

HCID 260Hydrogen BromideHCID 1046616-Hydroxyhexadecanoic acid

生成物 1

HCID 62039716-Bromohexadecanoic acid収率 99%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

16-Bromohexadecanoic acid was prepared by refluxing for 48 hrs 5.0 gr (18.35 mmole) of 16-hydroxyhexadecanoic acid in 24 ml of 1:1 v/v mixture of HBr (48% aqueous solution) and glacial acetic acid. Upon cooling, crude product was solidified inside the reaction vessel. It was filtered out and washed with 3×100 ml of cold water. Material was purified by recrystallization from n-hexane, filtered out and dried on high vacuum. 6.1 gr (99% yield) of the desired product were obtained.

後処理

  1. custom16-Bromohexadecanoic acid was prepared
  2. temperatureUpon cooling
  3. filtrationIt was filtered out
  4. washwashed with 3×100 ml of cold water
  5. customMaterial was purified by recrystallization from n-hexane
  6. filtrationfiltered out
  7. customdried on high vacuum

出典と根拠

ORDレコード
ord-81a650392c4247bcb66d79bfae8a6916
出典データセット
uspto-grants-2008_06
特許番号
US07381525B1

関連ノート

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