Phenacyl bromide → (3,4-Dichloro-phenyl)-(4-phenyl-thiazol-2-yl)-amine

HRID 130350

反応式

HRID 130350 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]([NH2:12])=[S:11])[CH:5]=[CH:6][C:7]=1[Cl:8].Br[CH2:14][C:15]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=O>C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[S:11][CH:14]=[C:15]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[N:12]=2)[CH:5]=[CH:6][C:7]=1[Cl:8]

参加物

4

反応物 2

HCID 6259Phenacyl bromideHCID 710776N-(3,4-Dichlorophenyl)thiourea

生成物 1

HCID 86228547(3,4-Dichloro-phenyl)-(4-phenyl-thiazol-2-yl)-amine収率 85%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To (3,4-Dichloro-phenyl)-thiourea (2 g, 9.04 mmol) in ethanol (35 mL) was added 2-Bromo-1-phenyl-ethanone and the solution was refluxed overnight. The reaction mixture was allowed to cool to room temperature and the resulting solid was filtered and washed with cold ethyl acetate to yield 2.45 g (85%) of an off-white solid. 1H NMR (300 MHz, DMSO-d6) δ 8.16 (d, J=1.8 Hz, 1H), 7.87 (d, J=7.5 Hz, 2 H), 7.61-7.29 (m, 6H); LCMS m/z 319 [M−1]

後処理

  1. temperaturethe solution was refluxed overnight
  2. filtrationthe resulting solid was filtered
  3. washwashed with cold ethyl acetate

出典と根拠

ORDレコード
ord-8a202ee4d2fb468b8ed0a91ab4595007
出典データセット
uspto-grants-2008_06
特許番号
US07381736B2

関連ノート

読み込み中…