Thionyl Chloride → 6-(3-Thienyl)-2-pyridinesulfonyl chloride

HRID 130405ノート

反応式

HRID 130405 の反応式
[Na+].[S:2]1[CH:6]=[CH:5][C:4]([C:7]2[N:12]=[C:11]([S:13]([O-:16])(=O)=[O:14])[CH:10]=[CH:9][CH:8]=2)=[CH:3]1.S(Cl)([Cl:19])=O>CN(C)C=O>[S:2]1[CH:6]=[CH:5][C:4]([C:7]2[N:12]=[C:11]([S:13]([Cl:19])(=[O:16])=[O:14])[CH:10]=[CH:9][CH:8]=2)=[CH:3]1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 59007067HCID 59007067、化合物

生成物 1

HCID 590070916-(3-Thienyl)-2-pyridinesulfonyl chloride

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide触媒

反応条件

温度
70 °C

実験手順

A mixture of 6-(3-thienyl)-2-pyridinesulfonic acid sodium salt (D9) and N,N-dimethylformamide (1 drop) in thionyl chloride (2 ml) was heated at 70° C. for 2 hours. After cooling to room temperature the solution was concentrated in vacuo and the residue co-evaporated with toluene (×2). The residue was triturated with diethyl ether to afford the title product (D10).

後処理

  1. temperatureAfter cooling to room temperature the solution
  2. concentrationwas concentrated in vacuo
  3. customThe residue was triturated with diethyl ether

出典と根拠

ORDレコード
ord-6e4c2f59a9c2482a8e1cde73eb428536
出典データセット
uspto-grants-2008_06
特許番号
US07381728B2

反応ノート

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