Bromine → 1-Bromo-2,4-dimethoxy-5-nitrobenzene

HRID 130411

反応式

HRID 130411 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N+:9]([O-:11])=[O:10])=[C:5]([O:12][CH3:13])[CH:4]=1.[Br:14]Br>C(Cl)(Cl)Cl>[Br:14][C:8]1[CH:7]=[C:6]([N+:9]([O-:11])=[O:10])[C:5]([O:12][CH3:13])=[CH:4][C:3]=1[O:2][CH3:1]

参加物

4

反応物 2

HCID 24408BromineHCID 786332,4-Dimethoxy-1-nitrobenzene

生成物 1

HCID 185436101-Bromo-2,4-dimethoxy-5-nitrobenzene

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒2 回

実験手順

1,3-Dimethoxy-4-nitrobenzene (5.0 g, 27 mmol) in chloroform (50 ml) at 0° C., was treated with a solution of bromine (1.68 ml, 33 mmol) in chloroform (50 ml). The solution was stirred with warming to room temperature for 4 hours, washed with 10% sodium thiosulfate solution and brine then dried over anhydrous magnesium sulfate and concentrated in vacuo. The crude product was used without further purification (D17). MS (ES+) m/e 262/264 [M+H]+.

後処理

  1. washwashed with 10% sodium thiosulfate solution and brine
  2. dry with materialthen dried over anhydrous magnesium sulfate
  3. concentrationconcentrated in vacuo
  4. customThe crude product was used without further purification (D17)

出典と根拠

ORDレコード
ord-3b86f43fe5bb4cde9afb7354e48b0a98
出典データセット
uspto-grants-2008_06
特許番号
US07381728B2

関連ノート

読み込み中…