Bromine → 1-Bromo-2,4-dimethoxy-5-nitrobenzene
反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N+:9]([O-:11])=[O:10])=[C:5]([O:12][CH3:13])[CH:4]=1.[Br:14]Br>C(Cl)(Cl)Cl>[Br:14][C:8]1[CH:7]=[C:6]([N+:9]([O-:11])=[O:10])[C:5]([O:12][CH3:13])=[CH:4][C:3]=1[O:2][CH3:1]参加物
4
実験手順
1,3-Dimethoxy-4-nitrobenzene (5.0 g, 27 mmol) in chloroform (50 ml) at 0° C., was treated with a solution of bromine (1.68 ml, 33 mmol) in chloroform (50 ml). The solution was stirred with warming to room temperature for 4 hours, washed with 10% sodium thiosulfate solution and brine then dried over anhydrous magnesium sulfate and concentrated in vacuo. The crude product was used without further purification (D17). MS (ES+) m/e 262/264 [M+H]+.
後処理
- washwashed with 10% sodium thiosulfate solution and brine
- dry with materialthen dried over anhydrous magnesium sulfate
- concentrationconcentrated in vacuo
- customThe crude product was used without further purification (D17)
出典と根拠
- ORDレコード
- ord-3b86f43fe5bb4cde9afb7354e48b0a98
- 出典データセット
- uspto-grants-2008_06
- 特許番号
- US07381728B2
反応ノート
読み込み中…